What Causes Osteoarthritis?
In the past, osteoarthritis (OA) was believed to be a wear and tear disease that affects the articular cartilage covering the ends of bones where they meet to form joints. New research shows OA to be a rather complex degenerative disease that may be caused by low-grade inflammation in the cartilage and the surrounding soft tissues that results in deterioration of the cartilage and a compromised joint structure. Although some risk factors for OA cannot be avoided (such as genetics, sex, and age), others are wholly in control of the patient. Controllable factors include: improperly treated sports injuries, lack of physical exercise, and overweight or obese body weight status.
International Journal of Molecular Science, March 2015